| Neuron: Basket cell | |
|---|---|
Transverse section of a cerebellar folium (Basket cell labeled at bottom left) |
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| Location | Cerebellum |
| Function | Inhibitory interneuron |
| Morphology | multipolar |
| Presynaptic connections | Parallel fibers |
| Postsynaptic connections | Purkinje cells |
| NeuroLex ID | nifext_160 |
Basket cells are inhibitory GABAergic interneurons found in several brain regions: the molecular layer of the cerebellum, the hippocampus, and the cortex.
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In the cerebellum, they synapse on the cell bodies of Purkinje cells, and are multipolar and stellate, with freely branching dendrites, which are dilated and knotty.
Hippocampal basket cells target somata and proximal dendrites of pyramidal neurons. Cortical[1] and hippocampal basket cells are parvalbumin-expressing and fast-spiking.
In the cortex, basket cells have sparsely branched axons giving off small pericellular, basket-shaped elaborations at several intervals along their length. There are three types of basket cells in the cortex, the small, large and nest type[2]: The axon of a small basket cell arborizes in the vicinity of that same cells dendritic range. In contrast, large basket cells innervate somata in different cortical columns. The nest basket cells are an intermediate form of the small and large cells, their axons are confined mainly to the same cortical layer as their somata.
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